When less is more - efficacy with less toxicity at the ED50
نویسندگان
چکیده
منابع مشابه
When Less is More
engine and airframe manufacturers for decades have cited the direct relationship between engine wear and high exhaust gas temperature (EGT) in recommending that operators use less than maximum takeoff thrust whenever possible. While the cost benefits of reduced-thrust takeoffs are thoroughly documented, the safety benefits are not as well understood. Thus, there is a common perception that usin...
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minimum level. Sometimes more really is more, and less really is less. But often, less is more. If all this piece does is open up the question of whether less is more —if all it does is remind the reader that this is a question, and that our answers to it have important repercussions— then it will have served its purpose. Many ethicists in the ancient tradition argued that human lives could be ...
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It has been suggested that external and/or internal limitations may paradoxically lead to superior learning (i.e., the concepts of “starting small” and “less is more”; Elman, 1993; Newport, 1990). In this paper, we explore what conditions might lead to a starting small effect. We report on four artificial grammar learning experiments with human participants. In Experiment 1A, we found an effect...
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I N THIS issue of ANESTHESIOLOGY, Li et al. 1 report on a laboratory study of resuscitation from uncontrolled hemorrhagic shock in rats. For those who have not followed this topic in the trauma literature, the results might seem counterintuitive—even heretical. Resuscitate to a lower blood pressure? How could that possibly be better? Although the physiologic reasons for this enigmatic effect ar...
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Fluorescent speckle microscopy is a new and simplified method for generating fiduciary marks on cellular structures. It promises to become the method of choice for studying polymer movement and dynamics in vivo.
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2017
ISSN: 0306-5251
DOI: 10.1111/bcp.13281